General Cell Based Assays
Eurofins Discoverx PathHunter eXpress CHRM1 U2OS β-Arrestin GPCR Assay, 10-Plate Kit. (93-0859E3CP0L)
The PathHunter CHRM1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. acetylcholine) based activation of CHRM1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CHRM1 and EA-tagged β-Arrestin-2. Activation of CHRM1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress TORC2 Nuclear Translocation Assay, 10pl Kit. (93-0813E3CP19L)
The PathHunter eXpress TORC2 Nuclear Translocation Assay provides an easy-to-use cell based assay to study drug candidates affecting the CRTC/CREB pathway. This kit assesses ligand (e.g. forskolin) based pathway activation via detection of resulting TORC2 (CRTC2) nuclear translocation. This product uses EFC technology. The included cell line overexpresses ProLabel-tagged TORC2 (CRTC2) and nuclear localized EA. Upon pathway activation, induced nuclear translocation of TORC2 leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress SREBP2 Nuclear Translocation Assay, 2pl Kit. (93-0830E3CP5M)
The PathHunter eXpress SREBP2 Nuclear Translocation Assay provides an easy-to-use cell based assay to study drug candidates affecting the cholesterol biosynthesis pathway. This kit assesses ligand (e.g. 5'-UMP) based pathway activation via detection of resulting SREBP2 nuclear translocation. This product uses EFC technology. The included cell line overexpresses ProLabel-tagged SREBP2 and nuclear localized EA. Upon pathway activation, induced nuclear translocation of SREBP2 leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Cayman Chemical 8dImethylamIno NAD sodIM 700ug
A derivative of NAD+; has been used in the screening of analog-sensitive PARP1 gatekeeper mutations
Cayman Chemical 33-BCRP InhIbItr 10mg
A BCRP inhibitor; sensitizes mitoxantrone-resistant H460/MX20 cells to mitoxantrone-induced cell death alone and in combination with UV radiation; sensitizes KB-C2 cells overexpressing P-gp to colchicine-induced cell death; increases intracellular accumulation of mitoxantrone in H460/MX20 cells at 5 µM
Eurofins Discoverx PathHunter eXpress mRXFP3 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0928E2MCP2L)
The PathHunter mRXFP3 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. relaxin-3) based activation of mRXFP3 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mRXFP3 and EA-tagged β-Arrestin-2. Activation of mRXFP3 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress NMBR CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0925E2CP2M)
The PathHunter NMBR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. neuromedin B) based activation of NMBR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged NMBR and EA-tagged β-Arrestin-2. Activation of NMBR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress HEK 293 RELA Nuclear Translocation Assay, 10-plate Kit. (93-0907E1CP0L)
The PathHunter eXpress HEK 293 RELA Nuclear Translocation Assay provides an easy-to-use cell based assay to study drug candidates affecting the NFκB pathway. This assay kit enables assessment of ligand (e.g. IL-1α) based pathway activation via detection of resulting RELA nuclear translocation. This product uses EFC technology. The included cell line overexpresses ProLink-tagged RELA and nuclear localized EA. Upon pathway activation, induced nuclear translocation of RELA leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress HTR1F U2OS β-Arrestin GPCR Assay, 10-Plate Kit. (93-0699E3CP0L)
The PathHunter HTR1F eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. serotonin) based activation of HTR1F GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged HTR1F and EA-tagged β-Arrestin-2. Activation of HTR1F stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Abcam Hydrogen Peroxide Assay Kit
Hydrogen Peroxide Assay Kit
The product is subject to the following: Abcam Restricted Use Statement
Lonza Walkersville Culture Media and Reagents Reagents 100 ML 1/EA
Sodium Pyruvate GMP Solution is sometimes added to cell culture as an additional source of energy since it is a key intermediate in the production of the high energy intermediate ATP within the cell Its normal concentration in MEM is 1 mM Sodium Pyruvate GMP Solution may help cells that are deficient in the nine enzymatic steps that break glucose down to pyruvate This BioWhittaker Cell Culture Media is produced according to cGMP and labelled For Further Manufacturing (FFM) GMP Products are intended for research or further manufacturing use only The products confirm with cGMP manufacturing compliance expectations for medical devices including 21 CFR Part 820 and ISO 13485 THIS PRODUCT IS NOT INTENDED FOR DIRECT THERAPEUTIC USE IN HUMANS
Meso Scale Discovery U-PLEX Human CA1 ASY
The Meso Scale Discovery U-PLEX Human CA1 Assay is a multiplex immunoassay kit for measuring CA1 in human serum plasma and cell culture supernatants It uses electrochemiluminescence detection offering high sensitivity a dynamic range of up to 5 logs and low sample volume needs The kit includes a 96-well plate with capture antibodies detection antibodies with electrochemiluminescent labels calibrators and diluent It quantifies CA1 levels with minimal hands-on time using an MSD instrument completing tests in 3 5 hours for efficient CA1 biomarker analysis
Echelon Biosciences Research Labs SHUTTLE PIP KIT PI(3 4 5)P3
Echelon Biosciences - Shuttle PIP Kit - P-9039 - PI(3,4,5)P3 This item is non returnable
Abcam Urokinase type Plasminogen Activator Human Chromogenic Activity Assay Kit
Urokinase type Plasminogen Activator Human Chromogenic Activity Assay Kit
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx PathHunter eXpress cyno CXCR1 HEK 293 β-Arrestin GPCR Assay, 2pl Kit. (93-0980E1CCP0M)
The PathHunter cyno CXCR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CXCL8/IL8) based activation of cyno CXCR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged cyno CXCR1 and EA-tagged β-Arrestin-2. Activation of cyno CXCR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Cynomolgus monkey version of this protein. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.